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The Research Foundation
The science, plainly stated.
Every ingredient in ThyroBase sits on top of peer-reviewed research. Bioactive forms. Premium sources. Co-formulated with qualified naturopaths, dietitians, research nutritionists, food scientists, and oncology pharmacists. No cherry-picked headlines, no overpromises. Just the studies, what they found, and how each one shaped the formulation.
Why the gap exists
In range doesn't always mean optimal.
"My tests are fine but I'm not" is the most common thing we hear from people living without a thyroid, or with one that no longer keeps up. A normal TSH reading does not rule out residual symptoms. ThyroBase exists for the gap between TSH normalisation and actual cellular wellbeing.
Post-thyroidectomy patients showed significantly lower Free T3 levels than non-thyroidectomy controls, despite normal TSH.
Gullo et al., 2011 · PLOS One63.5% of people on levothyroxine reported residual symptoms: fatigue, brain fog, mood issues. Even when tests came back "within range."
Freeman et al., 2019 · Innovations in PharmacyA 2023 systematic review (Benites-Zapata et al.) reported vitamin B12 deficiency in 27% of people with hypothyroidism.
Benites-Zapata et al., 2023 · Frontiers in EndocrinologyA 2020 review (Knezevic et al.) estimated that around 20% of T4-to-T3 conversion happens in the gut.
Knezevic et al., 2020 · Nutrients
The full reference list
Every study. Every finding.
| Study | Finding | Relevance |
|---|---|---|
| Gullo et al., 2011 · PLOS One | Lower Free T3 in thyroidectomy patients despite normal TSH | Why "in range" ≠ fine |
| Freeman et al., 2019 · Innovations in Pharmacy | 63.5% of people on levothyroxine report persistent residual symptoms | Scale of the care gap |
| Benites-Zapata et al., 2023 · Frontiers in Endocrinology | 27% B12 deficiency prevalence in hypothyroid patients | AM B12 rationale |
| Kobayashi et al., 2021 · Clin. Ped. Endocrinology | Selenium status impacts T3/T4 ratio | AM selenium rationale |
| Vargas-Uricoechea et al., 2024 · Int. J. Mol. Sci. | Zinc supports thyroid function and hormone conversion | AM zinc rationale |
| Rushton, 2002 · Clin. & Exp. Dermatology | Ferritin <70 µg/L linked to hair loss, even without anaemia | AM food-form iron rationale |
| Appunni et al., 2021 · BMC Endocrine Disorders | Vitamin D deficiency associated with hypothyroidism | AM vitamin D3 rationale |
| Knezevic et al., 2020 · Nutrients | ~20% of T4-to-T3 conversion occurs in the gut microbiome | PM probiotic rationale |
| Su et al., 2020 · JCEM | Gut dysbiosis patterns identified in hypothyroid patients | PM probiotic rationale |
| Abbasi et al., 2012 · JRMS (RCT) | Magnesium supplementation improved insomnia parameters | PM magnesium rationale |
| Yamadera et al., 2007 · Sleep & Biol. Rhythms (RCT) | Glycine before bed improved sleep quality and onset | PM glycine rationale |
| Kazemi et al., 2024 · Meta-analysis | Chamomile extract improves sleep quality and anxiety | PM chamomile rationale |
| Harit et al., 2024 · Cureus (RCT) | Passionflower reduces anxiety-driven insomnia | PM passionflower rationale |
Under the microscope
Spirulina, in the AM formula.
Every ingredient earned its place through published research, and every dose is declared in full on the pouch.
Earned its place.
No proprietary blends. No fairy dust. Every ingredient sits on top of peer-reviewed research, in the form your body can actually use, at a researched dose.
Who built this
Co-formulated with qualified naturopaths, dietitians, research nutritionists, food scientists, and oncology pharmacists.
Every ingredient and dose was reviewed by people who actually understood the brief. Manufactured in Australia to FSANZ standards.
Research nutritionists
Reviewed every ingredient choice and dose threshold against published research and known interactions with thyroid medication.
Naturopaths
Brought hands-on experience caring for people post-thyroidectomy and people with Hashimoto's into the formulation conversation.
Dietitians
Cross-checked daily nutrient targets and food-state context so the formula fits how people actually eat alongside their thyroid medication.
Food scientists
Made sure every form, blend and texture would actually deliver, not sit at the bottom of a glass or break down in storage.
Oncology pharmacists
Reviewed every ingredient for interactions with thyroid medication and post-thyroidectomy care, flagging anything that could compete with absorption.
The form matters
Why our ingredient forms are different.
Most supplements use the cheapest version of every nutrient. ThyroBase uses the form your body actually recognises and uses. The same active ingredient at a different bioavailability is a different product.
Pineapple, cardamom and spirulina in the AM formula.
Cacao, cinnamon, vanilla bean and chamomile in the PM formula.
| Nutrient | The cheap version | What's in ThyroBase |
|---|---|---|
| Vitamin C | Synthetic ascorbic acid | Acerola cherry extract (whole-food) |
| Vitamin B12 | Cyanocobalamin (synthetic) | Methylcobalamin (bioactive) |
| Iron | Iron sulfate (causes GI distress) | None added: naturally occurring in the food base |
| Zinc | Zinc oxide (around 10% absorption) | Zinc gluconate (well-absorbed) |
| Selenium | Sodium selenite (inorganic) | Selenomethionine (chelated) |
| Magnesium | Magnesium oxide (around 4% absorption) | Magnesium citrate (well-absorbed) |
| Vitamin D | Synthetic additive forms | Plant-source vitamin D3 |
On responsibility
What the science does, and does not, promise.
ThyroBase is built from peer-reviewed research on individual ingredients. We do not claim to treat, cure or reverse any disease, including thyroid disease. ThyroBase is designed to sit alongside your existing care.
What we can say
- Every ingredient is supported by published research relevant to its role in the formula
- Every dose is declared in full on the pouch nutrition panel, never hidden in proprietary blends
- Bioactive forms (methylcobalamin, selenomethionine, zinc gluconate, magnesium citrate) chosen over cheaper alternatives
- Exclusions (added iodine, kelp, soy isoflavones, added goitrogens) are based on documented interactions with thyroid function and thyroid medication
- ThyroBase is designed to support daily wellbeing as part of a broader routine
What we will never say
- That ThyroBase treats, cures, reverses or heals thyroid disease
- That ThyroBase replaces levothyroxine or any prescribed thyroid hormone replacement therapy
- That supplementation guarantees symptom resolution for every individual
- That outcomes from published studies will apply identically to every user
Real research. Real routine. Real people.
See the AM + PM system built on top of every study above. The System: four pouches, one box, 28 days.
Get yours$299 every 4 weeks on subscription · $329 one-time · 60-Day Empty Pouch Promise