
Selenium
200 mcg · selenomethionineCofactor for T4-to-T3 conversion. Up to 30% of post-thyroidectomy people sit at the bottom of the normal range here.
Each one chosen for its form, its dose, and the research behind it. No proprietary blends. No fairy dust. No filler.
Most thyroid-targeted supplements use the cheapest form of every nutrient. We co-formulated ThyroBase with dietitians, naturopaths, oncology pharmacists, and a FSANZ specialist around a single question: would I take this every day, for life. Every form below is the answer.
The cofactors your body needs to convert and use thyroid hormone effectively across the day.
Pineapple · Cardamom
Cofactor for T4-to-T3 conversion. Up to 30% of post-thyroidectomy people sit at the bottom of the normal range here.

Bioactive form, no conversion needed. 27% of hypothyroid people are deficient (Benites-Zapata, 2023).

Gentle on the gut, absorbed cleanly. Ferritin is one of the strongest correlates of hair shedding and energy.

Required for thyroid hormone synthesis. Pairs with selenium in T4-to-T3 conversion.

Twice as effective as D2 at raising serum levels. Linked to autoimmune thyroid in deficiency.

Whole-food source with bioflavonoid cofactors intact. Boosts iron absorption alongside the AM iron.

Yellow pea, brown rice, faba bean, pumpkin seed. Soy-free, complete amino acid profile.
The nutrients your body needs to settle, repair, and recover overnight. No caffeine. No melatonin. No sedation.
Chocolate · Cinnamon
The most documented mineral for sleep onset and quality (Abbasi, 2012, RCT). Citrate form, well-absorbed.

Lowers core body temperature, improves sleep quality at this dose (Yamadera, 2007, RCT). No grogginess.

Apigenin binds GABA receptors with calming effect. Useful for the "wired but tired" pattern.

Used clinically for anxiety-driven sleep onset. Pairs with chamomile and glycine for parasympathetic shift.

~20% of T4-to-T3 conversion happens in the gut microbiome (Knezevic, 2020). Multi-genus blend.

Feeds the live strains overnight. Supports gut barrier function — matters for hormone conversion.
The flavoring, sweetening, and finishing ingredients are held to the same standard as the actives. Whole-food sources. No artificial sweeteners. No flavor chemicals.

The heart of PM cocoa flavor. Naturally rich in magnesium and antioxidant polyphenols.

Real Madagascan vanilla bean, not synthetic flavoring extract. Adds depth and warmth to PM.

Adds the warm-spice signature to PM. Studied for glucose response and insulin sensitivity.

A pinch in PM for warmth, depth, and a subtle traditional calming note.

Low-glycemic Peruvian fruit. Caramel-toffee sweetness without the spike.

Zero-calorie, fruit-derived sweetness. No glycemic impact, no artificial chemistry.

Trace minerals and electrolyte balance. A pinch, not a season.

Dark leafy concentrate. Naturally rich in chlorophyll and trace micronutrients.

Algal protein and pigments. Iron-rich. Quiet plant nutrition in the AM blend.
What's not in the pouch matters as much as what is. Each exclusion has a reason — most tied to thyroid medication absorption or autoimmune triggers.
| Excluded | Why |
|---|---|
| Iodine | Unnecessary if you're on thyroid hormone medication. Can interfere with treatment and is documented to trigger or worsen autoimmune thyroid conditions in susceptible people. |
| Kelp | High iodine content by another name. Contraindicated for most people on thyroid medication. |
| Soy isoflavones | Documented to impair thyroid medication absorption and may interfere with hormone signalling. |
| Goitrogens | Counterproductive for thyroid function. Not in either pouch. |
| Glandular extracts | Unregulated hormone content from animal sources. Quality control is unreliable. |
| Caffeine and stimulants | Caffeine reduces thyroid medication absorption by 25 to 50% if taken too close to your dose. Guarana and synthetic stimulants amplify the wired-but-tired pattern. |
| Melatonin | We support the underlying physiology of sleep (glycine, magnesium, chamomile, passionflower) rather than override it with a hormone signal. |
| Synthetic fillers and gums | Xanthan, guar, carrageenan. None of them earn their place in a daily ritual. |
| Artificial sweeteners | Sucralose, aspartame, acesulfame-K. We use the natural sweetness of cocoa, vanilla, lucuma, and monk fruit. |
Every ingredient and dose was reviewed by people who actually understood the brief. Manufactured in Australia to FSANZ standards.
ThyroBase is a nutritional supplement and is not intended to diagnose, treat, cure, or prevent any disease. It is not a substitute for prescribed thyroid hormone replacement therapy. Always consult your healthcare professional before starting any supplement, especially if you are taking prescription medication.
See the full reference list on our science page, or start your monthly ritual with the only AM and PM system formulated specifically for life with a thyroid condition.
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